The 20-year-old played almost an hour of his latest return against Cheltenham on January 3, before picking up the injury in a friendly match this week.
Meanwhile, Wycombe have confirmed striker Drewe Broughton is surplus to requirements, midway through his proposed two-month loan from Southend United.
John Gorman looked at former Bristol City forward Marvin Brown this week, but won’t use his last loan signing of the season to bring in another striker.
Gorman has Ian Stonebridge as cover for front pairing Nathan Tyson and new signing Steve Claridge, while Craig Faulconbridge is sidelined with a knee injury.
The Chairboys have registered a defeat and two draws in the league, since their previous meeting with Macclesfield, the 2-1 reverse over the Christmas holidays.